Idiom Breakdown

louse up

COLLOQUIAL

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Definition

To mess up; to confuse; to put into a state of disorder.

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"To be loused up by Humbolt was really a kind of privilege. It was like being the subject of a two-nosed portrait by Picasso, or an eviscerated chicken by Soutine."
"The recent flu epidemic that loused up all my plans to see Pat Bond."

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