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Definition

Firstly; before anything else. Often used to introduce the first in a list of points to be made in conversation.

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Also Said As

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How People Actually Use It

1. First of all 2. A phrase, used by the intolerably unimaginative, to introduce the first of at least two dull, idiotic points in his/her "argument."

"Angry moron #1: First off, buddy, you're way outta line. Second-- Some other guy: Sorry to interrupt, but you're putting me to sleep. I'm gonna go home and take a nap."

Source: Urban Dictionary