Menopause.
put one's affairs in order
To prepare for the end of, or a radical change in, one's life.
road to Damascus
An important point in someone's life where a great change, or reversal…
change one's tune
To reconsider; rethink; to reach a different conclusion.
change one's mind
To decide differently than one had decided before.
change of heart
A change of one's opinion, belief or decision.
change hands
To become the property of someone else; to be bought or sold.